Pregabalin (Lyrica)

Pregabalin is a medicine used to treat neuropathic (nerve) pain and fibromyalgia. It is also used outside rheumatology to treat epilepsy and generalized anxiety disorder.

Pregabalin is a derived from the neurotransmitter gamma-aminobutyric acid (GABA). Gamma-aminobutyric acid plays an important role in the body’s central nervous system where it can reduce the excitability of neurons, the type of cell that the brain and nerves are made out of.

Taking Pregabalin

Pregabalin is available in oral capsules of different strengths that are taken twice or three times a day.

A usual starting dose is 75 mg (as one capsule) twice a day.

If you miss a dose, you can simply re-start the medication. It is only important to wean down Pregabalin slowly if you want to completely stop the medication.

Important Tests and Risks




Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Pregabalin in this short video:


Pregabalin Quick Reference Guide