Truxima

The normal dose is 1000 mg in each infusion. A steroid called methylprednisolone (Solumedrol) is usually given 30 minutes before the Truxima infusion to help prevent reactions to it.

For rheumatoid arthritis, when starting Truxima, the first dose is given on week 0. The second dose is given two weeks later. This cycle may be repeated again any time after 6 months depending on the patients’ response.

For vasculitis, when starting Truxima, doses are given each week for four (4) weeks in a row. Subsequent doses can be given according to the clinical response to the medication.

All patients should have hepatitis B testing done before starting Truxima.

In patients who have had hepatitis B or are a carrier of hepatitis B, Truxima risks causing the virus to become an active infection again.

Regular blood tests are not normally required for people who take Truxima. However, doctors treating arthritis will likely order occasional blood tests to monitor their patient’s blood counts and follow the activity of the disease.

In some people with inflammatory arthritis, the cells of the immune system become confused. They mistake the cells of the body’s own joints for foreign invaders and decide to “attack” them. Arthritis that is caused by this activity may be called an autoimmune disease.

The B-cell is a type white blood cell that forms part of the body’s immune system. It is partly responsible for this attack on the joints.

Truxima is a specially-designed protein called a monoclonal antibody that targets a specific protein found on the surface of B-cells called CD20. When Truxima binds to the surface of a B-cell, it causes their destruction.

By deleting B-cells from the body, Truxima works to suppress a part of the body’s immune system. Although this suppression may make it slightly harder for patients to fight off infections, it also helps to stabilize an overactive immune system.

Some side effects or reactions may occur for some patients during or shortly after the infusion.

Patients who take Truxima can very rarely develop a serious brain infection. Patients should call a doctor immediately if they experience changes in mental state, decreased vision, or problems with speech or walking. These symptoms may start gradually and get worse quickly.

MORE COMMON side-effects include:

• Abdominal pain, nausea, and diarrhea
• Sore muscles or joints
• Rash, hives, or itchiness
• Headaches, dizziness, or tingling
• Sore throat, fever, chills, & general weakness
• Increase in blood pressure

RARE side-effects include:

• Infusion Reaction – Many patients will react to the medication during or shortly after the infusion, most likely during the first infusion and less so with future infusions. Most of these reactions are not severe.
• Infection – As is the case with many medications used in the treatment of arthritis there is an increased risk of serious infections associated with the use of Truxima. Any infections or fevers should be taken very seriously and reviewed by a doctor.
• Rare brain infection – Patients have very rarely developed a rare brain infection called Progressive Multifocal Leukoencephalopathy while taking Truxima.
• Skin – Severe skin reactions have been reported with Truxima.
• Heart – Truxima has been associated with abnormal heart rhythms. Patients who have known heart rhythm problems should discuss them with their doctor to understand the potential impact of this medication.
• Blood Counts – Truxima can cause a drop in the numbers of white blood cells (which are needed to fight infection) or red blood cells (which carry oxygen). This is very rare and it is unusual for this to be a serious problem.

People who should NOT take Truxima include:

• Those who have had a previous serious allergic reaction to Truxima
• Women who are pregnant, planning on becoming pregnant, or breast feeding
• Patients with active infections (such as tuberculosis or hepatitis B)
• Patients with a history of hepatitis B or are carriers of the disease

Patients should call their doctor if they feel sick and want to stop, or they are concerned about any side effects.

Other reasons to call a doctor while taking Rituxan include:

• Fever or possible infection
• If another doctor has prescribed antibiotics to fight an infection
• Before having surgery
• Pregnancy or planning on becoming pregnant
• Planning to get any vaccinations
• Rash

Anyone who becomes pregnant while taking Rituxan should notify their doctor immediately.