Golimumab (Simponi)

Simponi (golimumab) is a biologic medicine that helps treat the pain and swelling of arthritis.

Simponi is used in the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, Ulcerative Colitis, and other types of arthritis.

Simponi belongs to a class of similar medications called Anti-Tumor Necrosis Factor (Anti-TNF) agents. These medications work by blocking Tumor Necrosis Factor (TNF), a type of signalling protein called a cytokine that is involved in systemic inflammation.

Simponi may be prescribed in combination with other medications like methotrexate.

Taking Simponi

Simponi is available as a monthly subcutaneous (under the skin) injection called Simponi SC, and an IV infusion called Simponi IV.

Simponi can take about 2 weeks before patients start to feel its effects. Some patients notice a benefit shortly after their first dose, while in others it can take several weeks. It can take 4 to 12 weeks before patients feel a lot of benefit.

Important Tests and Risks




Watch Canadian rheumatologist Dr. Andy Thompson introduce Simponi in this short video:


Simponi IV Quick Reference Guide
Simponi SC Quick Reference Guide


  • 02324776 (IV)
  • 02324784 (SC)
  • 02324776 (SC)