How Remsima Works

In some people with arthritis, a type of signalling protein (cytokine) called Tumour Necrosis Factor (TNF) is present in the blood and joints in excessive amounts where it increases inflammation (pain and swelling).

Remsima (infliximab) is another type of protein called a monoclonal antibody that works as a TNF blocker: it blocks the action of TNF.

In blocking TNF, Remsima suppresses the body’s immune system. Though this suppression can make it slightly harder for patients to fight off infections, it also helps to stabilize an overactive immune system.

In patients with arthritis, this medicine can:

  • Reduce the pain and swelling (inflammation) in arthritic joints
  • Improve day to day function
  • Prevent long-term damage caused by joint inflammation

Side Effects of Remsima

Patients taking Remsima (infliximab) should talk to their doctor if they are concerned about any side effects.

MORE COMMON side-effects include:

  • Abdominal pain, nausea, vomiting, and diarrhea.
  • Back pain, aching joints.
  • Rash, flushing.
  • Headaches.
  • Upper respiratory tract infections (such as sinusitis).

RARE side-effects include:

  • Infusion Reaction – Some patients may react to the medication during or shortly after it is administered.
  • Infection – There is an increased risk of serious infections associated with the use of this medication. Any infections or fevers should be taken very seriously and be reviewed by a doctor.
  • Nervous System – There have been very rare reports of some patients developing disorders that affect the nervous system (multiple sclerosis, seizures, or inflammation of the nerves of the eye) while taking Remsima. Fortunately, these reports are exceedingly rare.
  • Heart – Patients should inform their doctor if they have congestive heart failure as Remsima may make it worse.
  • Malignancy – Remsima has been associated with a small increased risk of developing cancer (<1%).

Who Should NOT Take Remsima

Patients who should NOT be taking Remsima or other brands of infliximab include:

  • Patients who have had a previous serious allergic reaction to Remsima
  • Possibly patients who have cancer or have had a past history of certain cancers
  • Patients who have congestive heart failure
  • Patients who have Lupus or multiple sclerosis
  • Patients with active infections (such as tuberculosis)

Anyone who becomes pregnant while taking this medication should tell their doctor.

When to Call a Doctor

Patients taking Remsima should call their doctor if they feel sick and want to stop, or if they are concerned about any side effects.

Other reasons to call a doctor while taking Remsima include:

  • Fever or possible infection
  • Another doctor has prescribed antibiotics to fight an infection
  • Planning for surgery
  • Becoming pregnant, or planning on pregnancy
  • Planning on any vaccinations
  • Developing a rash

Remsima Video

Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Remsima.