Denosumab (Prolia)

Prolia (denosumab) is a biologic medicine used to treat and prevent thinning of the bones (called osteoporosis) and other diseases where loss of bone mass is a concern.

Prolia is a type of protein called a monoclonal antibody that works by disrupting a natural process in the body that breaks down the bones. This gives a different natural process that builds up the bones a chance to get ahead and build up bone density.

Taking Prolia

Prolia is available in a pre-filled syringe with a normal dose of 60 mg. It is taken once every 6 months by injection. The injection is usually given by a doctor or nurse.

To help build the bones, patients should take calcium and vitamin D while taking Prolia. Doctors will tell their patients the right amount of calcium and vitamin D to take. Patients should take any supplements exactly as prescribed by their doctor.

Important Tests and Risks




Watch Canadian rheumatologist Dr. Andy Thompson introduce Prolia in this short video:


Prolia Quick Reference Guide


  • 02343541 (Injection)