Apremilast (Otezla)

Otezla (apremilast) is a medication used to used to treat psoriasis and the joint pain and tenderness of psoriatic arthritis.

Otezla works by inhibiting an enzyme called phosphodiesterase-4 (PDE4) that is involved in the body’s inflammatory response. Otezla belongs to a class of drugs known as phosphodiesterase-4 inhibitors.

Taking Otezla

Otezla is available in 10 mg, 20 mg, and 30 mg oral tablets.

It can take up to 16 weeks for Otezla to work. It is important for patients starting Otezla to keep taking the medicine regularly in order to give it a chance.

The manufacturer of Otezla offers a support program to Canadian patients that are prescribed the medication:

Patient support program enrolment forms

Important Tests and Risks




Otezla Quick Reference Guide


  • 02434318 - Starter Kit
  • 02434334 - 30 mg Tablet