How Orencia Works

In some people with inflammatory arthritis, the body’s immune system becomes confused. It mistakes the cells of the body’s own joints for foreign invaders and attacks them. When the body’s immune system attacks normal body cells by mistake, it is called an autoimmune disease.

Orencia is a synthetic protein called a fusion protein that is a type of modified antibody. It was created by researchers to suppress the body’s immune system. It works by preventing an important immune system cell, the T-cell, from becoming activated, or turned on. In patients whose T-cells are attacking their joints by mistake, this effect helps reduce the attack.

Patients can benefit from reduced pain and swelling (inflammation) in the joints, improved day-to-day function, and the prevention of long-term damage.

The immune system is an important system in the body that fights off attacks from dangerous invaders like bacteria and viruses that make people sick. As Orencia suppresses the immune system, patients taking the medication will have a slightly harder time fighting off infections. At the same time, Orencia can help to stabilize overactive immune systems in patients whose T-cells are attacking things that they shouldn’t.

Side Effects of Orencia

Orencia’s (abatacept’s) ability to suppress the immune system can make it harder for patients to fight infections. It is important for patients to tell their doctor if they have a fever or infection, or if they think they might have an infection.

MORE COMMON side-effects include:

  • Nausea & diarrhea
  • Back pain
  • Rash, flushing
  • Headaches or dizziness
  • Upper respiratory tract infections (such as sinusitis). Patients who have an infection should contact their doctor.

RARE side-effects include:

  • Injection Site Reaction: Redness, swelling, and discomfort around the area injected
  • Infection: Any infections or fevers should be taken seriously and reviewed by a doctor.
  • Lungs: Abatacept may worsen symptoms of COPD (emphysema) and pneumonia
  • Malignancy: Abatacept be associated with a small increased risk of developing certain types of cancer. Concerned patients should discuss this risk with their rheumatologist.

How to minimize the side-effects of Orencia (abatacept):

  • All patients should have a TB (tuberculosis) skin test and a chest x-ray before starting Orencia
  • Take Orencia as prescribed by a doctor.

Patients should talk to their doctor if they are concerned about any side effects.

Orencia can simply be stopped. It does not need to be “weaned off” like some other medications. However, a patients’ arthritis will likely “flare” for a few weeks after stopping. Patients should talk to their doctor if they want to stop taking this medication.

Who Should NOT Take Orencia

People who should NOT be taking Orencia (abatacept) include:

  • Patients who have had a previous serious allergic reaction to Orencia
  • Women who are pregnant, planning on becoming pregnant, or are breast feeding
  • Patients who have cancer, or have had a past history of certain types of cancers
  • Patients with active infections (such as tuberculosis)
  • Patients who are about to have surgery should consult their doctor about when to stop/start Orencia.

Anyone who becomes pregnant while taking Orencia should notify their doctor. This is a newer medication and it is unknown if it is safe for pregnancy or breastfeeding. Therefore, it is best to AVOID PREGNANCY while on this medication. All women of child bearing potential who are taking Orencia should use reliable contraception.

When to Call a Doctor

Patients taking Orencia (Abatacept) should call their doctor if they feel sick and want to stop, or if they are concerned about any side effects.

Other reasons to call a doctor while taking Orencia include:

  • Fever
  • Infection: Patients with an infection (or think they have an infection), or if they have been prescribed antibiotics should call their doctor
  • Severe injection site reaction
  • Rash: Patients who develop a bad rash
  • Surgery: Orencia should be stopped before surgery. It can be restarted once things have healed and there is no sign of infection. Patients having surgery should talk to their doctor about when to stop the medicine.
  • Vaccinations: Patients should discuss all vaccinations with their doctor because some vaccines are not advisable while taking Orencia.
  • Emphysema (COPD) and Pneumonia: Orencia can worsen symptoms of emphysema (COPD) and make pneumonia worse. Patients who have emphysema or COPD should tell their doctor.
  • History of Cancer: Orencia has very rarely been associated with developing certain types of cancer. Patients who have had cancer in their past should make sure their doctor knows.

Orencia Video

Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Orencia.