Etanercept (Erelzi)

Erelzi (etanercept) is a biologic medicine that helps the pain and swelling of arthritis. It is used in the treatment of Rheumatoid Arthritis, Psoriatic Arthritis, Ankylosing Spondylitis, and other types of arthritis.

Erelzi works by blocking Tumor Necrosis Factor (TNF), a type of signalling protein (called a cytokine), that is involved in systemic inflammation. Erelzi belongs to a class of similar medications called Anti-Tumor Necrosis Factor agents.


Erelzi is a type of medicine that is called a biosimilar. A biosimilar is a type of biologic medication that is designed to be identical to an existing biologic medication, but is created using a different process.

Erelzi is a biosimilar of Enbrel. Both medications are known by the same generic name: etanercept. Biosimilars are often cheaper than the original medication.

Taking Erelzi

Enbrel is available as a subcutaneous (under the skin) injection that can be taken at home.

The manufacturer of Erelzi offers a support program to Canadian patients that are prescribed the medication:

Patient support program enrolment forms

Important Tests and Risks




Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Erelzi in this short video:


Erelzi Quick Reference Guide


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