How Didrocal Works

The body features an ongoing process called bone remodeling where bones are constantly broken down (bone resorption) and rebuilt. Bones are broken down by a type of cell called osteoclasts and are built back up by a type of cell called osteoblasts.

In patients with osteoporosis and Paget’s disease, too much bone is being broken down too quickly.

All bisphosphonates, including Didrocal, bind to the surface of bones and slow down the bone resorption process. They are toxic to the osteoclasts that break down bone. Slowing down the resorption process gives the body more time to build up and strengthen the bones.

Didrocal, unlike other bisphosphonates, can also prevent bone calcification. This is the process where bones accumulate calcium. This effect is usually not desired in patients who have osteoporosis, but it may be desirable in treating other medical conditions.

Side Effects of Didrocal

Patients should talk to their doctor if they are concerned about any side effects.

The most common side effect of Didrocal is stomach upset, pain, bloating, and nausea. To minimize side effects, it is best to take Didrocal as prescribed: in the morning before any food or drink other than water. It is best to wait at least one hour after taking Didrocal before taking any other medication or eating or drinking anything else but water.

  • Nausea & diarrhea – The most common side effect of Didrocal is stomach upset, pain, bloating, and nausea. Didrocal can irritate the lining of the stomach, esophagus, or intestine. This is rare. It can result in stomach pain or trouble swallowing.
  • Headache & dizziness – Didrocal can rarely cause a headache
  • Muscle & bone pain – Didrocal can rarely cause bone, muscle, or joint pain.

Didrocal should not be taken during pregnancy or breastfeeding. Patients who become pregnant should stop taking the medicine and contact their doctor.

Who Should NOT Take Didrocal

Patients who should NOT be taking Didrocal include:

  • Patients who are allergic to Didrocal or any ingredient in this medicine
  • Patients who are allergic to other biphosphonate medications
  • Patients that are pregnant or breast-feeding

Anyone who becomes pregnant while taking Didrocal should notify their doctor immediately.

When to Call a Doctor

Patients should call their doctor if they feel sick and want to stop, or they you are concerned about any side effects.

Other reasons to call a doctor while taking Didrocal include:

  • Stomach pain or trouble swallowing
  • Pregnant or Planning Pregnancy
  • New severe pain in the jaw
  • Upcoming surgery

Didrocal Video

Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Didrocal.