How Cymbalta Works

Cymbalta is a serotonin-norepinephrine reuptake inhibitor, or SNRI. Serotonin and norepinephrine are two natural neurotransmitters that coordinate signals in the brain and other parts of the nervous system. They are known to affect mood and are believed to be involved in controlling the experience of pain.

After serotonin and norepinephrine are released by neurons (cells in the brain and nerves) to help transmit a signal, they re-enter cells in a process called reuptake where they are stored and are no longer active. As a reuptake inhibitor, Cymbalta blocks this process and thus increases the levels of free serotonin and norepinephrine in the body, where they continue to play an active role in the transmission of nerve signals.

Increased levels of these neurotransmitters has found to be beneficial in patients suffering from types of depression and anxiety, and has also been shown to improve the symptoms of pain experienced by patients with fibromyalgia and other types of neurologic pain.

Scientists aren’t sure exactly how Cymbalta helps make fibromyalgia and neurologic pain feel better, but, these conditions are not very well understood either!

Scientists think that this type of pain is due to changes in the nervous system that cause too many signals to fire off along pain pathways. It is thought that the increased levels of serotonin and norepinephrine caused by Cymbalta work to calm down these signals. The result is a reduction in pain experienced by the patient.

Side Effects of Cymbalta

Nausea, drowsiness, insomnia, and dizziness are the most common side effects of Cymbalta.

Cymbalta can irritate the liver. Occasional blood tests help doctors monitor for this. Patients are advised to avoid alcohol to avoid irritating the liver and minimize the risk of this side effect.

Other possible side effects include:

  • Nausea & Constipation – Cymbalta can cause pain in the stomach, nausea, or vomiting. It can also cause dry mouth and constipation
  • Dizziness & confusion – Cymbalta can make people feel dizzy. It can rarely cause agitation or confusion.
  • Blurry vision – Cymbalta can cause blurry vision. Patients should tell their doctor if they have glaucoma before starting this medicine.
  • Blood pressure – Cymbalta can rarely cause an increase in blood pressure. Doctors will monitor this. Patients should tell their doctor if they have high blood pressure.
  • Increased sweating – Cymbalta can rarely cause an abnormal increase in sweating.
  • Headache – Cymbalta can rarely cause a headache.
  • Bladder problems – Cymbalta can cause urine retention and difficulty voiding.

Cymbalta has not been studied in pregnancy. Patients should let their doctor know if they are planning to get pregnant or if they are breastfeeding.

Who Should NOT Take Cymbalta

TBD: need better content

  • Patients with liver disease
  • Patients who have alcohol abuse problems

Patients who want to stop taking Cymbalta should talk to their doctor. It is best to stop taking this medicine slowly.

When to Call a Doctor

People taking Cymbalta should call their doctor if they feel sick and want to stop, or if they are concerned about any side effects.

Other reasons for patients taking Cymbalta to call a doctor include:

  • Dizziness, confusion, or agitation
  • Blurry vision
  • Increased blood pressure
  • Severe stomach pain
  • Pregnancy or planning pregnancy

Cymbalta Video

Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Cymbalta.