Leflunomide (Arava)

Arava (Leflunomide) is a Disease Modifying Anti-Rheumatic Drug (DMARD) that suppresses the immune system to treat rheumatoid arthritis, psoriatic arthritis, and other types of arthritis.

Leflunomide belongs to a class of medications known as pyrimidine synthesis inhibitors.

Taking Leflunomide

Leflunomide is available as oral tablets in 10 mg, 20 mg, and 100 mg doses.

A dose of 10 mg or 20 mg is usually taken once a day as a single tablet. In some cases, it may be prescribed every other day.

Rheumatologists used to start Leflunomide with three loading doses of 100 mg per day. This is not usually done any more because there is a greater risk of side effects at this dose.

Important Tests and Risks




Watch rheumatologist Dr. Andy Thompson introduce Leflunomide in a short 3-minute video:


Leflunomide Quick Reference Guide