How Actonel Works

The body features an ongoing process called bone remodelling where bones are constantly broken down (called bone resorption) and built back up. Bones are broken down by a type of cell called osteoclasts and are built back up by a type of cell called osteoblasts.

In patients with osteoporosis and Paget’s disease, too much bone is being broken down too quickly.

All bisphosphonate medications, including Actonel, bind to the surface of bones and slow down the bone resorption process. This works because it is toxic to the osteoclasts that break down bone.

When Actonel slows down the resorption process, it gives the body more time to build up and strengthen the bones.

Side Effects of Actonel

Patients should talk to their doctor if they are concerned about any side effects.

The most common side effect of Actonel is stomach upset, pain, bloating, and nausea. To minimize side effects, it is best to take Actonel as prescribed: in the morning before any food or drink other than water. It is best to wait at least one hour after taking Actonel before taking any other medication or eating or drinking anything else but water.

  • Nausea & diarrhea – The most common side effect of Actonel is stomach upset, pain, bloating, and nausea. Actonel can irritate the lining of the stomach, esophagus, or intestine. This is rare. It can result in stomach pain or trouble swallowing.
  • Headache & dizziness – Actonel can rarely cause a headache
  • Muscle & bone pain – Actonel can rarely cause bone, muscle, or joint pain.

Actonel should not be taken during pregnancy or breastfeeding. Patients who become pregnant should stop taking the medicine and contact their doctor.

Who Should NOT Take Actonel

Patients who should NOT be taking Actonel include:

  • Patients who are allergic to Actonel or any ingredient in this medicine
  • Patients who are allergic to other biphosphonate medications
  • Patients who are pregnant or breast-feeding

Patients who become pregnant while taking Aclasta should notify their doctor immediately.

When to Call a Doctor

Patients should call their doctor if they feel sick and want to stop, or they you are concerned about any side effects.

Other reasons to call a doctor while taking Actonel include:

  • Stomach pain or trouble swallowing
  • Pregnant or Planning Pregnancy
  • New severe pain in the jaw
  • Upcoming surgery

Actonel Video

Watch Dr. Andy Thompson, a Canadian rheumatologist, introduce Actonel.