Calcium Pyrophosphate Deposition Disorder

Calcium pyrophosphate deposition disorder (CPPD) is a chronic (long-term) type of arthritis that causes joint problems due to an accumulation of calcium pyrophosphate crystals in and around the joints and tendons. It most commonly affects the knees, wrists, and hips.

Calcium pyrophosphate deposition can cause calcification of the tendons and ligaments which can be severe and debilitating. This typically affects the tendons around the shoulder joints (rotator cuff) and the Achilles tendon (the heels) but any joint can be affected.

The disease is sometimes presents similar to gout because both diseases are caused by a build-up of crystals in the joints that trigger a response by the immune system.

Calcium pyrophosphate deposition typically affects men and women over the age of 50. It is often found in and around joints typically affected by osteoarthritis, especially the knees.

Understanding Calcium Pyrophosphate Deposition Disorder


Calcium Pyrophosphate Deposition Disorder Quick Reference Guide