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Medications > Zolendronate > Zoledronate (Aclasta) – pictopamphlet

ZOLEDRONATE (Aclasta) [Zole-ed-ROW-nate]

How to use this medicaiton

What is it

Zoledronate is a medication used to treat and prevent thinning of the bones (called osteoporosis) and to treat a condition called Paget’s disease.

Take it once a year by intravenous (IV)

Zoledronate is given once a year by a 15 minute intravenous (IV) infusion.

What you need to do

Take calcium & vitamin D

To help build your bones you should take calcium & vitamin D while taking zoledronate. Your doctor will tell you the right amount of calcium and vitamin D for you.

Don’t get pregnant or breastfeed

Do not take zoledronate if you are pregnant or plan to become pregnant.

Pain in the jaw

Medicines like zoledronate have been associated with a very rare problem with the jaw (osteonecrosis). This problem has been seen after dental work. Let your doctor know if you develop sudden pain in the jaw.

Bone mineral density (BMD) testing

Your doctor will monitor your response to zoledronate by testing your BMD.  This is usually done every 1 to 3 years.  Talk to your doctor.

Side effects & important things to know

Fever & flu-like symptoms

After receiving zoledronate, some patients have developed a fever and flu-like symptoms including “feeling out of sorts”, chills, fatigue, and weakness.  These symptoms are usually mild to moderate and go away after a few days.

Nausea & diarrhea

Zoledronate can cause nausea, vomiting, and diarrhea.

Headache & dizziness

Zoledronate can rarely cause a headache or dizziness.

Muscle & bone pain

Zoledronate can cause bone, muscle, or joint pain.  This can be severe but is rare.

Heart problems

Zoledronate has been associated with abnormal heart rhythms (atrial fibrillation).  Tell your doctor if you have a heart rhythm problem.

When should I call my doctor

Please call if you are concerned

  • If you feel sick after the infusion

If you are concerned about any side effects

Other Reasons to Call your Doctor:

Stomach pain or trouble swallowing

Pregnant or Planning Pregnancy

New severe pain in the jaw

If you are having surgery

Other important information

Stopping Zolendronate

You can simply stop taking zoledronate. You do not need to wean off it. Please call your doctor if you stop the medication.